ARN-3236

ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), with IC50s of [1][2].

Product Specifications

CAS Number

[1613710-01-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Salt-inducible Kinase (SIK)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ARN-3236.html

Purity

99.66

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=CC=C(C2=CNC3=NC=CC(C4=CSC=C4)=C32)C(OC)=C1

Molecular Formula

C19H16N2O2S

Molecular Weight

336.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Lombardi MS, et al. SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype. J Leukoc Biol. 2016 May;99 (5) :711-21.|[2]Zhou J, et al. A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts. Clin Cancer Res. 2017 Apr 15;23 (8) :1945-1954.