Hydrochlorothiazide-13C6

Hydrochlorothiazide-13C6 is the 13C labeled Hydrochlorothiazide[1]. Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[2][3][4].

Product Specifications

CAS Number

[1261396-79-5]

Product Name Alternative

HCTZ-13C6

UNSPSC

12352005

Hazard Statement

H302

Target

Potassium Channel; TGF-beta/Smad

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hydrochlorothiazide-13c6.html

Purity

99.61

Solubility

10 mM in DMSO

Smiles

O=S1([13C]2=[13CH][13C](S(N)(=O)=O)=[13C](Cl)[13CH]=[13C]2NCN1)=O

Molecular Formula

C 13C6H8ClN3O4S2

Molecular Weight

303.70

Precautions

P264-P270-P330-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8 (6) : p. 793-802.|[3]Magdy M Abdelquader, et al. Inhibition of Co-Crystallization of Olmesartan Medoxomil and Hydrochlorothiazide for Enhanced Dissolution Rate in Their Fixed Dose Combination. AAPS PharmSciTech. 2018 Dec 1720 (1) :3.|[4]Jinghong Luo, et al. Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. Cardiovasc Ther. 2017 Apr35 (2) .