β-Zearalanol-d4

β-Zearalanol-d4 is a deuterium labeled Beta-Zearalanol (HY-N6740) [1]. Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells[2]. Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid[3].

Product Specifications

CAS Number

[1778735-09-3]

UNSPSC

12352005

Hazard Statement

H410

Target

Apoptosis; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Purity

99.24

Solubility

10 mM in DMSO

Smiles

OC1=C2C(CCCCC([2H])([2H])[C@@H](C([2H])([2H])CC[C@@H](OC2=O)C)O)=CC(O)=C1

Molecular Formula

C18H22D4O5

Molecular Weight

326.42

Precautions

H410

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Yang F, et al. Melatonin alleviates β-zearalenol and HT-2 toxin-induced apoptosis and oxidative stress in bovine ovarian granulosa cells. Environ Toxicol Pharmacol. 2019 May;68:52-60.|[3]Marin DE, et al. Cytotoxic and inflammatory effects of individual and combined exposure of HepG2 cells to zearalenone and its metabolites. Naunyn Schmiedebergs Arch Pharmacol. 2019 Aug;392 (8) :937-947.