GR 103691

GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h) D3 over hD4 and hD1 sites[1].

Product Specifications

CAS Number

[162408-66-4]

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gr-103691.html

Purity

99.91

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(C1=CC=C(C2=CC=C(C(C)=O)C=C2)C=C1)NCCCCN3CCN(C4=CC=CC=C4OC)CC3

Molecular Formula

C30H35N3O3

Molecular Weight

485.62

References & Citations

[1]Audinot V, et al. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+) -S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther. 1998 Oct;287 (1) :187-97.