1,2,3,4,7,8-Hexachlorodibenzofuran

1,2,3,4,7,8-Hexachlorodibenzofuran (1,2,3,4,7,8-HxCDF) promotes the gene expressions of CYP1A1, CYP1B1, and aryl hydrocarbon receptor repressor (AhRR) in human peripheral blood lymphocytes (PBLs) . 1,2,3,4,7,8-Hexachlorodibenzofuran activates the ethoxyresorufin-Odeethylase, achieves 20% of the maximum response caused by TCDD with a BMR20TCDD of 0.115-0.143 nM[1].

Product Specifications

CAS Number

[70648-26-9]

Product Name Alternative

1,2,3,4,7,8-HxCDF

UNSPSC

12352005

Hazard Statement

H301, H319, H413

Target

Aryl Hydrocarbon Receptor; Cytochrome P450

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-2-3-4-7-8-hexachlorodibenzofuran.html

Smiles

ClC1=CC2=C(C=C1Cl)C3=C(Cl)C(Cl)=C(Cl)C(Cl)=C3O2

Molecular Formula

C12H2Cl6O

Molecular Weight

374.86

Precautions

H301, H319, H413

References & Citations

[1]van Ede KI, et al., Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicol Lett. 2014 Apr 7;226 (1) :43-52.