RAD51 Inhibitor B02
RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM.
Product Specifications
CAS Number
[1290541-46-6]
Product Name Alternative
B02
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; RAD51
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RAD51_Inhibitor_B02.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : ≥ 37 mg/mL
Smiles
O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CC=CN=C3)=NC4=C1C=CC=C4
Molecular Formula
C22H17N3O
Molecular Weight
339.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Huang F, et al. Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. ACS Chem Biol. 2011 Jun 17;6 (6) :628-35.|[2]Huang F, et al. A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts. PLoS One. 2014 Jun 27;9 (6) :e100993.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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