CDK9-IN-35

CDK9-IN-35 (compound 10j) is an inhibitor of CDK9/Cyclin T1 with an IC50 value of 10.2 nM and against the HCT-116 cell line with an IC50 value of 20 nM[1].

Product Specifications

UNSPSC

12352211

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk9-in-35.html

Smiles

COC1=C(N=C(N=C1)NC2=CC=C(C(Cl)=C2)OCC3=CC=CC(F)=C3)NCC4=CC=C(C=C4)S(C)(=O)=O

Molecular Formula

C26H24ClFN4O4S

Molecular Weight

543.01

References & Citations

[1]Gopalakrishnan Venkatesan, et al. Design, synthesis, molecular modeling and evaluation of 2,4-diaminopyrimidine analogues as promising colorectal cancer drugs. Bioorg Chem. 2024 Sep 29:153:107854.