ACPA (Negative Control), Monoclonal Antibody (Clone E4NG-Mutant)

This antibody is a negative control for the E4NG antibody (product number 1061006) . It is the mutated version of the E4NG antibody, with identical sequence, methods of production/purification and format to E4NG except two mutations in the paratope (W48M & S51A) . This antibody has neglectable or no affinity to citrulline and has no known cross-reactivity to other antigens. It may have minimal non- specific binding to CCP2, the cyclic citrullinated peptide (s) of the second generation of the anti-CCP test. This antibody can be paired as a negative control with E4NG antibody (product number 1061006) for detecting citrullinated antigens. This negative control antibody is not sold separately. Anti-citrullinated protein antibodies (ACPA) are autoantibodies linked to rheumatoid arthritis (RA) . In RA research, collagen-induced arthritis (CIA) or CAIA mouse models are used to study ACPA's role in disease mechanisms like inflammation and joint damage.

Collagen Type II, Monoclonal Antibody (Clone M2139), 100ug; Collagen Type XI, Monoclonal Antibody, 100ug; ACC1, Monoclonal Antibody, 100ug; ACC4 (IgG1), Monoclonal Antibody, 100ug; ACC4 (IgG2b), Monoclonal Antibody, 100ug