Collagen Type I, Bovine

Highly Purified type I native collagen from bovine skin. Lyophilized Type I collagen is the most abundant collagen and is found in connective tissues including tendon, ligament, dermis and blood...

Product Specifications

Background

Highly Purified type I native collagen from bovine skin. Lyophilized Type I collagen is the most abundant collagen and is found in connective tissues including tendon, ligament, dermis and blood vessel. It is the major component and the primary determinant of tensile strength of the extracelluar matrix (ECM) . It is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells etc. In addition, collagen I can self-assemble into a 3-D superamolecular gel in vitro, making it an ideal biological scaffold to promote more in vivo-like cellular morphology and function. Symbols/Related Terms: COL1A1 COL1A2 osteogenesis imperfecta

Short Description

Collagen Type I, Bovine, 10 mg

Source

Bovine (calf) skin. Collagen was extracted from washed dissected tissue into dilute acetic acid after pepsin treatment. Collagen type I was purified by using differential salt precipitation.

Purification

Partial pepsin digestion in acidic conditions and differential salt precipitation.

Assay Type

Protein

Purity

Bovine Type I Collagen (90%) other non-collagen proteins (<0.5%)

Form

Lyophilized, 10 mg/vial

Reconstitution

Use 0.1 M acetic acid, pH 3.0

Storage Conditions

Collagen dissolved in acetic acid is stable at 4 °C for 1 month. Lyophilized collagen long term storage (2 years) at -20°C or lower.

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