Collagen Type I, Goat

Highly Purified type I native goat collagen. Lyophilized. Reconstitute to 10 mg/mL Type I collagen is the most abundant collagen and is found in connective tissues including tendon, ligament, dermis and blood vessel. It is the major component and the primary determinant of tensile strength of the extracelluar matrix (ECM) . It is widely used as a thin layer on tissue-culture surfaces to enhance the attachment and proliferation of a variety of cells including endothelial cells, fibroblasts, hepatocytes, epithelial cells etc. In addition, collagen I can self-assemble into a 3-D superamolecular gel in vitro, making it an ideal biological scaffold to promote more in vivo-like cellular morphology and function. Symbols/Related Terms: COL1A1 COL1A2 osteogenesis imperfecta

Goat tissue. Collagen was extracted from washed dissected tissue into dilute acetic acid after pepsin treatment. Collagen type I was purified by using differential salt precipitation.

Use 0.5 M acetic acid, pH 2.5 at 4°C. Collagen solubility 10 mg/ml. Dissolved collagen retains immunologic properties of native collagen. Structure of native collagen confirmed by ability to form microfibrils.

Collagen Type I (Atelocollagen) Porcine, 30 mg; Collagen Type I (Atelocollagen), Bovine, 30 mg; Collagen Type I (Atelocollagen), Mouse, 1 mg; Collagen Type I (Atelocollagen), Rat, 30 mg; Collagen Type I and III, Bovine, 10 mg