BEND-6 Recombinant Protein (Human)
The human BEND-6 recombinant protein consists of a single, non-glycosylated polypeptide chain containing 302 amino acids (1-279 aa) . BEN domain-containing protein 6 (BEND6) is a neural BEN-solo factor that functions similarly...
Product Specifications
Background
The human BEND-6 recombinant protein consists of a single, non-glycosylated polypeptide chain containing 302 amino acids (1-279 aa) . BEN domain-containing protein 6 (BEND6) is a neural BEN-solo factor that functions similarly to the Drosophila co-repressor Insensitive. BEND6 binds to the mammalian CSL protein CBF1 and antagonizes Notch-dependent target activation. Its interaction with Notch- and CBF1-regulated enhancers is enhanced by CBF1 and inhibited by activated Notch. In utero electroporation experiments have shown that overexpression of BEND6 hinders Notch-mediated self-renewal of neocortical neural stem cells, thereby promoting neurogenesis.
Short Description
BEND-6 Recombinant Protein (Human), 20ug
Volume
20μg / vial
Assay Type
Cell Signaling Pathways
Purity
> 95%, as determined by SDS-PAGE
Form
Soluble
Buffer
This protein is supplied in 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.1M NaCl.
Molecular Weight
33.6kDa
Related Products
PD1 (PDCD1, CD279), Active, Recombinant Protein, Human, 20ug; CD80 (CTLA-4 / B7-1) Recombinant Protein, Human, 5ug; CD86 (CTLA-4 / B7-2) Recombinant Protein, Human, 20ug; Galectin-9 (LGALS9) Recombinant Protein, Human, 10ug; TIGIT Recombinant Protein, Human, 10ug
Host or Source
E.coli
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