BEND-6 Recombinant Protein (Human)

Product Specifications

Background

The human BEND-6 recombinant protein consists of a single, non-glycosylated polypeptide chain containing 302 amino acids (1-279 aa) . BEN domain-containing protein 6 (BEND6) is a neural BEN-solo factor that functions similarly to the Drosophila co-repressor Insensitive. BEND6 binds to the mammalian CSL protein CBF1 and antagonizes Notch-dependent target activation. Its interaction with Notch- and CBF1-regulated enhancers is enhanced by CBF1 and inhibited by activated Notch. In utero electroporation experiments have shown that overexpression of BEND6 hinders Notch-mediated self-renewal of neocortical neural stem cells, thereby promoting neurogenesis.

Short Description

BEND-6 Recombinant Protein (Human), 20ug

Volume

20μg / vial

Assay Type

Cell Signaling Pathways

Purity

> 95%, as determined by SDS-PAGE

Form

Soluble

Buffer

This protein is supplied in 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.1M NaCl.

Molecular Weight

33.6kDa

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