PDGF-BB Recombinant Protein (Human)
The human PDGF-BB recombinant protein consists of a homodimeric, non-glycosylated, polypeptide chain containing two 109 amino acids. Platelet-derived growth factor (PDGF) is a dimeric glycoprotein composed of two disulfide-stabilized polypeptide chai...
Product Specifications
Background
The human PDGF-BB recombinant protein consists of a homodimeric, non-glycosylated, polypeptide chain containing two 109 amino acids. Platelet-derived growth factor (PDGF) is a dimeric glycoprotein composed of two disulfide-stabilized polypeptide chains, A and B, forming heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) . PDGF signals through receptor tyrosine kinases PDGFRα and PDGFRβ and activates pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT. It is a potent mitogen for mesenchymal cells such as fibroblasts, glial cells, and vascular smooth muscle cells. It is implicated in atherosclerosis, glomerulonephritis, cancer, and vascular smooth muscle cell contraction. PDGF-AA regulates VEGF expression in non-small cell lung carcinomas and mediates the proliferation and differentiation of oligodendrocyte progenitor cells. PDGF-AA is also used to differentiate human pluripotent stem cell-derived neural progenitor cells into oligodendrocyte precursor cells.
Short Description
PDGF-BB Recombinant Protein (Human), 10ug
Volume
10μg / vial
Assay Type
Cell Signaling Pathways
Purity
> 95%, as determined by SDS-PAGE
Form
Lyophilized
Molecular Weight
24.3kDa
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Host or Source
E.coli
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