FGF-8 Recombinant Protein (Human)
The human FGF-8 recombinant protein consists of a non-glycosylated polypeptide chain containing 194 amino acids. Fibroblast Growth Factor 8 (FGF8) plays a crucial role in early vertebrate brain patterning, with its...
Product Specifications
Background
The human FGF-8 recombinant protein consists of a non-glycosylated polypeptide chain containing 194 amino acids. Fibroblast Growth Factor 8 (FGF8) plays a crucial role in early vertebrate brain patterning, with its inhibition leading to the absence of mesencephalic and cerebellar regions and resulting in early embryonic death. FGF8 can bind to all four FGF receptors, triggering the phosphorylation of ERK1/2 and activating the RAS-MAPK pathway. This growth factor, along with others like Sonic Hedgehog (Shh), is essential for the specification and differentiation of midbrain dopaminergic neurons.
Short Description
FGF-8 Recombinant Protein (Human), 25ug
Volume
25μg / vial
Assay Type
Cell Signaling Pathways
Purity
> 98%, as determined by SDS-PAGE
Form
Lyophilized
Molecular Weight
22.5kDa
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Host or Source
E.coli
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