GITR (CD357, AITR) Recombinant Protein, Human

The human Glucocorticoid-induced TNFR-related protein (GITR, CD357, AITR) is a recombinant protein consisting of a single glycosylated polypeptide chain with 145 amino acids (26-162aa) . Glucocorticoid-induced TNFR-related protein (GITR), also known as TNFRSF18, GITR, and CD357, AITR (Activation-Inducible TNFR family member is a member of the TNF receptor superfamily. It significantly stimulates both acquired and innate immunity by promoting T effector function and inhibiting regulatory T cell (Treg) suppression. GITR is broadly expressed on various immune cells, particularly Tregs, natural killer (NK) cells, antigen-presenting cells (APCs), and tumor cells. Upon T cell activation, GITR expression is upregulated on Tregs and CD4+ and CD8+ effector T cells, making it an attractive target for cancer immunotherapy due to its potential to enhance immune responses against tumors. Abbreviations: GITR, CD357, GITR-D, TNFRSF18, Glucocorticoid-induced TNFR-related protein, AITR, Tumor necrosis factor receptor superfamily member 18, CD357, Activation-inducible TNFR family receptor, UNQ319/PRO364.

PD1 (PDCD1, CD279), Active, Recombinant Protein, Human, 20ug; CD80 (CTLA-4 / B7-1) Recombinant Protein, Human, 5ug; CD86 (CTLA-4 / B7-2) Recombinant Protein, Human, 20ug; Galectin-9 (LGALS9) Recombinant Protein, Human, 10ug; TIGIT Recombinant Protein, Human, 10ug