OX40 (CD134, TNFRSF4) Recombinant Protein, Human

The human OX40 is a recombinant protein consists of a single glycosylated polypeptide chain with 425 amino acids (29-214aa) . OX40, also known as TNF Receptor Superfamily Member 4 Human Recombinant (TNFRSF4) or CD134, is a member of the TNF receptor superfamily and functions as a crucial T cell co-stimulatory molecule. It coordinates with other co-stimulatory molecules like CD28, CD40, CD30, CD27, and 4-1BB to regulate immune response activation. OX40 plays a vital role in antigen-specific T cell expansion, survival, and cytokine production. Upon engagement of the TCR by antigen-presenting cells and co-stimulation by CD40-CD40L and CD28-B7, OX40 is upregulated on CD4+ and CD8+ T cells, enhancing their proliferation, survival, activation, and differentiation into effector and memory T cells. Additionally, OX40 inhibits the immunosuppressive function of regulatory T cells (Tregs) and is primarily expressed by activated antigen-presenting cells, which stimulate antigen-specific T cells through OX40/OX40L interactions. Abbreviations: TNFRSF4, ACT35 Antigen, OX40L Receptor, Tumor Necrosis Factor Receptor Superfamily Member 4, OX40 Cell Surface Antigen, TXGP1L, Tumor Necrosis Factor Receptor Superfamily, Member 4, OX40 Antigen, IMD16, Tax-Transcriptionally Activated Glycoprotein 1 Receptor, ATC35 Antigen, Lymphoid Activation Antigene ACT35, TNF Receptor Superfamily Member 4, CD134 Antigen, OX40 Homologue, TAX Transcriptionally-Activated Glycoprotein 1 Receptor.

PD1 (PDCD1, CD279), Active, Recombinant Protein, Human, 20ug; CD80 (CTLA-4 / B7-1) Recombinant Protein, Human, 5ug; CD86 (CTLA-4 / B7-2) Recombinant Protein, Human, 20ug; Galectin-9 (LGALS9) Recombinant Protein, Human, 10ug; TIGIT Recombinant Protein, Human, 10ug