CTLA-4 (CD152) Recombinant Protein, Human
The human CTLA-4 is a recombinant protein consists of a single glycosylated polypeptide chain with 149 amino acids (36-161aa) . CTLA-4 (CD152) is the first identified co-inhibitory molecule and clinically targeted immune...
Product Specifications
Background
The human CTLA-4 is a recombinant protein consists of a single glycosylated polypeptide chain with 149 amino acids (36-161aa) . CTLA-4 (CD152) is the first identified co-inhibitory molecule and clinically targeted immune checkpoint receptor, expressed on T cells where it primarily downregulates early T cell activation. CTLA-4 counteracts CD28 activity, a T cell co-stimulatory receptor, by binding to CD80 (B7-1) and CD86 (B7-2) with higher affinity. By outcompeting CD28 for these ligands, CTLA-4 diminishes T cell activation and delivers inhibitory signals, playing crucial roles in both innate and adaptive immune responses. Abbreviations: IDDM12, CELIAC3, GSE, CTLA-4, CD152.
Short Description
CTLA-4 (CD152) Recombinant Protein, Human, 25ug
Volume
25μg / vial
Assay Type
Cell Signaling Pathways
Purity
> 95%, as determined by SDS-PAGE
Form
Soluble
Molecular Weight
15.9kDa
Storage Conditions
Stable at 4°C for one month or stored in the dark at -20°C long-term.
Related Products
PD1 (PDCD1, CD279), Active, Recombinant Protein, Human, 20ug; CD80 (CTLA-4 / B7-1) Recombinant Protein, Human, 5ug; CD86 (CTLA-4 / B7-2) Recombinant Protein, Human, 20ug; Galectin-9 (LGALS9) Recombinant Protein, Human, 10ug; TIGIT Recombinant Protein, Human, 10ug
Host or Source
E. coli
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