TIGIT Recombinant Protein, Human

The human T-Cell Immunoreceptor with Ig and ITIM Domains (TIGIT) is a recombinant protein consisting of a single glycosylated polypeptide chain with 359 amino acids (22-141aa) . T-cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSIG9, VSTM3, WUCAM, V-set is an immune checkpoint, offering potential as an immunotherapeutic target. This transmembrane glycoprotein receptor, featuring an Ig-like V-type and an ITIM in its cytoplasmic region, is expressed on activated and memory T cells, NK cells, and Tregs. Immune checkpoints, known as co-inhibitory receptors, are vital for regulating immune cell function to maintain tolerance and prevent autoimmunity. Established checkpoints like PD-1 and CTLA-4 play significant roles in autoimmune diseases and cancer, with their blockade already approved for cancer therapy. Given the suppressive microenvironments of tumors with elevated immune checkpoints on tumor-infiltrating lymphocytes, targeting TIGIT and similar receptors holds promise for advancing cancer treatment. Abbreviations: V-set and transmembrane domain-containing protein 3, V-set and immunoglobulin domain-containing protein 9, WUCAM, VSIG9, VSTM3

PD1 (PDCD1, CD279), Active, Recombinant Protein, Human, 20ug; CD80 (CTLA-4 / B7-1) Recombinant Protein, Human, 5ug; CD86 (CTLA-4 / B7-2) Recombinant Protein, Human, 20ug; Galectin-9 (LGALS9) Recombinant Protein, Human, 10ug; OX40L (CD134L, CD252) Recombinant Protein, Human, 10ug