CD86 (CTLA-4 / B7-2) Recombinant Protein, Human
The human CD86 (CTLA-4 Counter-Receptor B7-2) is a recombinant protein consisting of a single glycosylated polypeptide chain with 223 amino acids (31-247aa) . CD86 (B7-2) and CD80 (B7-1) are molecules upregulated on...
Product Specifications
Background
The human CD86 (CTLA-4 Counter-Receptor B7-2) is a recombinant protein consisting of a single glycosylated polypeptide chain with 223 amino acids (31-247aa) . CD86 (B7-2) and CD80 (B7-1) are molecules upregulated on Antigen Presenting Cells (APCs) upon activation of Toll-Like Receptor (TLR) pathways, playing a crucial role in T cell activation by binding to the co-stimulatory molecule CD28. CTLA-4 (CD152) is expressed on activated T cells and binds to CD80 and CD86 with higher affinity than CD28, leading to the suppression of T cell activation. Blocking CTLA-4 signaling prolongs T cell activation and enhances anti-tumor responses. CTLA-4 was the first immune checkpoint targeted for cancer treatment. Abbreviations: BU63, B7-2/CD86, B7.2, CD28LG2, B70, CTLA-4 counter-receptor B7.2, CD86, T-lymphocyte activation antigen CD86, LAB72, Activation B7-2 antigen.
Short Description
CD86 (CTLA-4 / B7-2) Recombinant Protein, Human, 20ug
Volume
20μg / vial
Assay Type
Cell Signaling Pathways
Concentration
0.5 mg/mL (Refer to the vial label for the concentration.)
Purity
> 95%, as determined by SDS-PAGE
Form
Soluble
Buffer
This protein is supplied in PBS (pH 7.4) and 10% glycerol.
Molecular Weight
25.6kDa
Storage Conditions
Stable at 4°C for one month or stored in the dark at -20°C long-term.
Related Products
PD1 (PDCD1, CD279), Active, Recombinant Protein, Human, 20ug; CD80 (CTLA-4 / B7-1) Recombinant Protein, Human, 5ug; Galectin-9 (LGALS9) Recombinant Protein, Human, 10ug; TIGIT Recombinant Protein, Human, 10ug; OX40L (CD134L, CD252) Recombinant Protein, Human, 10ug
Host or Source
SF9
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC740009-500 1x 500 µL
MART-1 / Melan-A (M2-7C10), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC400257-100 1x 100 µL
Cytokeratin, HMW (AE-3), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC942340-500 1x 500 µL
Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) (TYRP1/2340R), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941952-100 1x 100 µL
CD21 (Mature B-Cell & Follicular Dendritic Cell Marker) (CR2/1952), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881983-100 1x 100 µL
Carcinoembryonic Antigen (CEA) / CD66 (C66/1983R), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details