Collagen Type II, Monoclonal Antibody (Clone CIIC1)
This antibody binds specifically to the C1 epitope on triple helica collagen type 2. It cross-reacts with mouse, rat, chicken, baboon and horse. Collagen type II, encoded by the COL2A1 gene, ...
Product Specifications
Background
This antibody binds specifically to the C1 epitope on triple helica collagen type 2. It cross-reacts with mouse, rat, chicken, baboon and horse. Collagen type II, encoded by the COL2A1 gene, is a crucial component of cartilage and plays a vital role in maintaining joint integrity. In mouse models of arthritis, such as collagen-induced arthritis, COL2A1 is studied for its role in cartilage degradation, a key feature of conditions like rheumatoid arthritis and osteoarthritis. Research on COL2A1 helps in understanding arthritis mechanisms and developing new treatments.
Short Description
Collagen Type II, Monoclonal Antibody (Clone CIIC1), 100ug
Cross Reactivity
Mouse, Rat, Chicken, Horse, Baboon
Immunogen
Derived from B cells of collagen type 2 immunized DBA/1 mice.
Clone
CIIC1
Applications
Immunohistochemistry (IHC), ELISA, in vivo functional assays, such as Collagen-Induced Arthritis.
Assay Type
Antibodies
Dilution
It is recommended that the user determine the optimal dilution for their application. The typical starting working dilutions are IHC 1:100 and ELISA 1:1000.
Form
This antibody is soluble and supplied in PBS.
Related Products
Collagen Type II, Monoclonal Antibody (Clone M2139), 100ug; Collagen Type XI, Monoclonal Antibody, 100ug; ACC1, Monoclonal Antibody, 100ug; ACC4 (IgG1), Monoclonal Antibody, 100ug; ACC4 (IgG2b), Monoclonal Antibody, 100ug
Isotype
Human IgG1, k
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