Cartilage Oligomeric Matrix Protein (COMP), Monoclonal Antibody (Clone 16B5)

This antibody binds to the coiled-coil domain or pentamer COMP. It cross-reacts with mouse, rat and human. Cartilage Oligomeric Matrix Protein (COMP) is a disulfide-linked pentameric proteoglycan primarily found in cartilage, but also present in other joint tissues such as meniscus, tendon, synovial fibroblasts, and osteoblasts. As a member of the thrombospondin family, COMP stimulates type II collagen fibril formation. It is released into the blood when cartilage is damaged, making it a valuable biomarker for predicting cartilage destruction in inflammatory joint diseases like rheumatoid arthritis (RA) and osteoarthritis (OA) .

It is recommended that the user determine the optimal dilution for their application. The typical starting working dilutions are for IHC 1:100, ELISA 1:200-1:500.

Collagen Type II, Monoclonal Antibody (Clone M2139), 100ug; Collagen Type XI, Monoclonal Antibody, 100ug; ACC1, Monoclonal Antibody, 100ug; ACC4 (IgG1), Monoclonal Antibody, 100ug; ACC4 (IgG2b), Monoclonal Antibody, 100ug