ACC4 (IgG2b), Monoclonal Antibody
This antibody is an anti-citrullinated protein antibody (ACPA) that on Collagen alpha-1 (II) chain binds specifically to citrullinated C1 epitope on alpha-chain (position 359–369) . It cross-reacts with mouse, bovine, and potentially...
Product Specifications
Background
This antibody is an anti-citrullinated protein antibody (ACPA) that on Collagen alpha-1 (II) chain binds specifically to citrullinated C1 epitope on alpha-chain (position 359–369) . It cross-reacts with mouse, bovine, and potentially human. Citrullination of proteins is a post-translational modification in which arginine is converted into citrulline by a family of enzymes called peptidylarginine deiminases (PADs) . Proteins are susceptible to citrullination during inflammatory processes, and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis.
Short Description
ACC4 (IgG2b), Monoclonal Antibody, 100ug
Cross Reactivity
Mouse, Human, potentially Human
Immunogen
Generated by immunization of DBA/1 or (B10.Q x DBA/1) F1 mice with Protein- arginine deiminase type-4 (PAD4) -treated triple-helical CII peptides containing T and B cell epitopes.
Clone
ACC4
Applications
Immunohistochemistry (IHC), in-vivo functional studies such Collagen- Induced Arthritis (CIA), and evoked pain-behavior
Assay Type
Antibodies
Dilution
It is recommended that the user determine the optimal dilution for their application. The typical starting working dilutions are for IHC 1:100.
Form
This antibody is soluble and supplied in PBS.
Related Products
Collagen Type II, Monoclonal Antibody (Clone M2139), 100ug; Collagen Type XI, Monoclonal Antibody, 100ug; ACC1, Monoclonal Antibody, 100ug; ACC4 (IgG1), Monoclonal Antibody, 100ug; ACPA, Monoclonal Antibody (Clone E4NG), 100ug
Isotype
Mouse IgG2b, k
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