ACC4 (IgG1), Monoclonal Antibody

This antibody is an anti-citrullinated protein antibody (ACPA) that, on Collagen alpha-1 (II) chain, binds specifically to citrullinated C1 epitope on alpha-chain (position 359–369) . It cross-reacts with mouse, bovine, and potentially human. Citrullination of proteins is a post-translational modification in which arginine is converted into citrulline by a family of enzymes called peptidylarginine deiminases (PADs) . Proteins are susceptible to citrullination during inflammatory processes, and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis.

Collagen Type II, Monoclonal Antibody (Clone M2139), 100ug; Collagen Type XI, Monoclonal Antibody, 100ug; ACC1, Monoclonal Antibody, 100ug; ACC4 (IgG2b), Monoclonal Antibody, 100ug; ACPA, Monoclonal Antibody (Clone E4NG), 100ug