ACC1, Monoclonal Antibody

This antibody binds ACC1 to the citrullinated triple-helical collagen type II (CII) epitope (position 359-369), the C1 epitope. The ACC1 antibody recognizes the second citrulline at position 365 in mouse Collagen Type II. The antibody binds to flexible triple-helical Collagen Type II determinants and many citrullinated CII peptides and was found to cross-react with several non-citrullinated epitopes on native Collagen Type II. It cross-reacts with mouse and human. Citrullination of proteins is a post-translational modification in which arginine is converted into citrulline by a family of enzymes called peptidylarginine deiminases (PADs) . Proteins are susceptible to citrullination during inflammatory processes, and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis.

It is recommended that the user determine the optimal dilution for their application. The typical starting working dilutions are for IHC 1:100 and ELISA 1:200-1:500.

Collagen Type II, Monoclonal Antibody (Clone M2139), 100ug; Collagen Type XI, Monoclonal Antibody, 100ug; ACC4 (IgG1), Monoclonal Antibody, 100ug; ACC4 (IgG2b), Monoclonal Antibody, 100ug; ACPA, Monoclonal Antibody (Clone E4NG), 100ug