Bisindolylmaleimide V

Bisindolylmaleimide V is a cell-permeable negative control for protein kinase C inhibition studies with an IC50 value over 100 µM[1]. Bisindolylmaleimide V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 of 8 µM[2].

Product Specifications

CAS Number

[113963-68-1]

Product Name Alternative

BIM V

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ribosomal S6 Kinase (RSK)

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bisindolylmaleimide-v.html

Purity

97.75

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

O=C(C(C1=CNC2=C1C=CC=C2)=C3C4=CNC5=C4C=CC=C5)N(C)C3=O

Molecular Formula

C21H15N3O2

Molecular Weight

341.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Lazareno S, et al. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol. 1998 Nov 6;360 (2-3) :281-4.|[2]Marmy-Conus N, et al. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70 (s6k) /p85 (s6k) : implications for the analysis of S6K signalling. FEBS Lett. 2002 May 22;519 (1-3) :135-40.