Anti-Stat1 Antibody

Our Stat1 primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Stat1 and is protein a purified. It is great for use in ELISA, WB, ICC, IP.

Product Specifications

Background

The stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Stat1 is expressed as two variants of 84 and 91 kDa. Stat1 proteins contain SH2 and SH3 domains, and are components of the interferon-stimulated gene factor 3 (ISGF3) complex. This complex is the primary transcription activator induced by the binding of interferon to its receptors. In response to activation by various cytokines and growth factors, stat1 subunits become phosphorylated at tyrosine 701. This leads to translocation of stat1 to the nucleus, resulting in formation of an active ISGF3 complex. Active ISGF3 modulates the transcription of the interferon-stimulated genes. Thus, phosphorylation of Tyr-701 is critical for gene expression mediated by various cytokines and growth factors.

Short Description

Our Stat1 primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Stat1 and is Protein A purified. It is great for use in WB, ICC, IP.

Synonyms

Stat1a, Stat1b, ISGF3, Stat1alpha, Stat1beta

Gene Name

STAT1

UniProt

P42224

Reactivity

Human, Mouse, and Rat

Immunogen

Clone (M249) was generated from a recombinant protein from human Stat1. This sequence has high homology to the conserved region in rat and mouse stat1 a and b.

Target

Stat1

Clonality

Monoclonal

Clone

M249

Conjugation

Unconjugated

Applications

ELISA, WB, ICC, IP

Field of Research

Cell Signaling, Oncoproteins, Transcription Regulation

Format

Protein A Purified

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Modification

GOmAb

Molecular Weight

84/91

Precautions

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.