Anti-Integrin β4 (Cytoplasmic region) Antibody

The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins. Activation of IκBα occurs through both serine and tyrosine phosphorylation events. Activation through phosphorylation at Ser-32 and Ser-36 is followed by proteasome-mediated degradation, resulting in the release and nuclear translocation of active NF-κB. This pathway of IκBα regulation occurs in response to various NF-κB-activating agents, such as TNFα, interleukins, LPS, and irradiation. An alternative pathway for IκBα regulation occurs through tyrosine phosphorylation of Tyr-42 and Tyr-305. Tyr-42 is phosphorylated in response to oxidative stress and growth factors. This phosphorylation can lead to degradation of IκBα and NF-κB-activation. In contrast, Tyr-305 phosphorylation by c-Abl has been implicated in IκBα nuclear translocation and inhibition of NF-κB-activation. Thus, tyrosine phosphorylation of IκBα may be an important regulatory mechanism in NF-κB signaling.

Our Integrin β4 (Cytoplasmic region) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Integrin β4 (Cytoplasmic region) and is Protein A purified. It is great for use in WB, ICC.

Clone M126 was generated from a recombinant protein containing amino acid residues in the cytoplasmic region of human Integrin β4. This sequence is found in all three Integrin β4 isoforms and has 90% homology with rat and mouse Integrin β4.

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.