Anti-Integrin β3 (Extracellular region) Antibody

Integrins are cell adhesion molecules that can mediate bidirectional transfer of signals across the plasma membrane. The cytoplasmic domains of integrin family members interact with components of the signal transduction apparatus within cells. Integrin receptors contain noncovalently associated α and β subunits that consist of a large extracellular region (the ligand-binding domain), a short transmembrane region, and a cytoplasmic domain of varying length. In mammals, at least 17 α subunits and 8 β subunits have been identified and these proteins can heterodimerize to form at least 22 different receptors. The integrin β2 subunit associates with integrin αL to form a receptor for ICAM family members. Integrin β2/αL is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

Our Integrin β3 (Extracellular region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Integrin β3 (Extracellular region) and is Protein A purified. It is great for use in WB, ICC.

Clone M581 was generated from a recombinant protein containing amino acid residues in the extracellular region of human Integrin β3. This sequence has high homology with rat and mouse Integrin β3, and has low homology to other integrin family members.

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

This antibody detects a 100kDa* protein corresponding to the molecular mass of Integrin β3 on SDS-PAGE immunoblots of human platelets and endothelial cells (HUVEC) .