Anti-Grb2 Antibody

Our Grb2 primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Grb2 and is protein a purified. It is great for use in ELISA, WB, ICC, IP.

Product Specifications

Background

Crk and Grb2 family adaptor proteins are involved in a variety of cell signaling pathways related to human diseases. These adaptors have Src homology 2 (SH2) and Src homology 3 (SH3) domains, which are docking sites for several signaling proteins, including receptors, kinases, and GTPase regulators. In addItion, other protein-protein interactions may also utilize Crk and Grb2 domain interactions to modulate cell signaling pathways. The DOCK family of proteins (DOCK3, DOCK4, and DOCK5) can interact with Crk and may be important Crk effector proteins. The cell cycle regulator p27Kip1 can interact with Grb2, and this implicates Grb2 activity in cell signaling pathways that alter cell cycle progression.

Short Description

Our Grb2 primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat Grb2 and is Protein A purified. It is great for use in WB, ICC, IP.

Synonyms

Grb

Gene Name

GRB2

UniProt

P62994

Reactivity

Human, Mouse, and Rat

Immunogen

Clone (M331) was generated from a full length recombinant rat Grb2 protein. This sequence has high homology to human and mouse Grb2.

Target

Grb2

Clonality

Monoclonal

Clone

M331

Conjugation

Unconjugated

Applications

ELISA, WB, ICC, IP

Field of Research

Cell Signaling, Growth Factor Signaling, Oncoproteins

Format

Protein A Purified

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Modification

GOmAb

Molecular Weight

Precautions

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Notes

Protein A purified culture supernatant.

WB Dilution

1:1000

IP Dilution

1:50

Specificity

This antibody detects a 24 kDa* protein corresponding to the molecular mass of Grb2 on SDS-PAGE immunoblots of rat PC12.

ICC Dilution

1:50

Quality Control

Western blots performed on each lot.

Host or Source

Mouse

Physical Properties

Liquid

Isotype

IgG1

Immunogen Species

Rat

WB Quality Control

Quality Control: WB

RRID

AB_2113024

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