Anti-CD147/Emmprin/Basigin (Extracellular region) Antibody

Our CD147/Emmprin/Basigin (Extracellular region) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human CD147/Emmprin/Basigin (Extracellular region) and is protein g purified. It is great for use in ELISA, WB.

Product Specifications

Background

D147 (Basigin/EMMPRIN) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily. CD147 is a glycosylated protein with four known isoforms with isoform 2 being the most abundantly expressed. In many cancers, CD147 is overexpressed and stimulates the secretion of extracellular matrix metalloproteinases by tumor fibroblasts, which can promote tumor progression. CD147 is co-expressed with the amino acid transporter, CD98h, in metabolically active cells such as lymphocytes, macrophages, and tumor cells. CD147 interaction with caveolin and cyclophilins regulates its functions, and this protein may function outside of tumor cells through cell shedding and microvesicle release.

Short Description

Synonyms

Basigin, 5F7, Collagenase stimulatory factor Extracellular matrix metalloproteinase, EMMPRIN, Leukocyte activation antigen M6, OK blood group antigen, Tumor cell-derived collagenase stimulatory factor, TCSF, CD147, BSG

Gene Name

CD147

UniProt

P35613

Reactivity

Human

Immunogen

Clone (M052) was generated from a proprietary antigen related to the native human CD147 expressed in NCI-H1915 lung cancer cell line.

Target

CD147/Emmprin/Basigin (Extracellular region)

Clonality

Monoclonal

Clone

M052

Conjugation

Unconjugated

Applications

ELISA, WB

Field of Research

Cell Adhesion Molecules, Immunology, Oncoproteins

Format

Protein G Purified

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Molecular Weight

38-58

Precautions

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Notes

Protein G purified culture supernatant.

WB Dilution

1:2000

Specificity

Clone M052 mouse monoclonal antibody detects a 38-58 kDa* protein on SDS-PAGE immunoblots of human SK-MES1, MDA-MB-231, MeWo, A431, LNCaP, and NCI-H1915 cells, as well as human brain tissues. The antibody works for western blot and ELISA detection of CD147.