Anti-Caveolin-1 (N-terminal region) Antibody

Our Caveolin-1 (N-terminal region) primary antibody from PhosphoSolutions is rabbit polyclonal. It detects chicken, human, mouse, and rat Caveolin-1 (N-terminal region) and is antigen affinity purified. It is great for use in ELISA, WB, ICC.

Product Specifications

Background

Caveolins are the primary structural components of the plasma membrane microdomains, caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified, and each has distinct expression patterns. Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion and apoptosis. Caveolins can interact with various signaling molecules, including G-proteins, receptor tyrosine kinases, PKCs, and Src family kinases. Phosphorylation at Tyr-14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins, while phosphorylation at Ser-80 regulates caveolin binding to the ER membrane and entry into the secretory pathway.

Short Description

Synonyms

Caveolin1, vip21

Gene Name

CAV1

UniProt

Q03135

Reactivity

Chicken, Human, Mouse, and Rat

Immunogen

The antibody was generated from a recombinant protein that includes amino acids in the N-terminal region of human Caveolin-1.

Target

Caveolin-1 (N-terminal region)

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

ELISA, WB, ICC

Field of Research

Cardiovascular, Oncoproteins

Format

Antigen Affinity Purified

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Molecular Weight

Precautions

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Notes

Affinity purified rabbit serum

WB Dilution

1:2000

Specificity

This antibody detects a 21 kDa* protein corresponding to the apparent molecular mass of caveolin-1 on SDS-PAGE immunoblots of human A431 cells and rabbit spleen fibroblasts.