Anti-Caspase-8 (C-terminal region) Antibody

Our Caspase-8 (C-terminal region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human Caspase-8 (C-terminal region) and is protein a purified. It is great for use in ELISA, WB.

Product Specifications

Background

The caspases are a group of cysteine enzymes, which cleave proteins in response to intrinsic and extrinsic pathways that cause apoptotic cell death. The caspases can be grouped into two subgroups based on their roles in apoptosis. Initiator caspases (caspases 2, 8, 9, and 10) are activated through the apoptosis-signaling pathways and activate the effector caspases (caspases 3, 6, and 7) which carry out apoptosis. Caspase cascades are initiated through assembly of multiprotein complexes that trigger activation of the initiator caspases, which are then released and are able to activate the downstream effector caspases.

Short Description

Our Caspase-8 (C-terminal region) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human Caspase-8 (C-terminal region) and is Protein A purified. It is great for use in WB.

Synonyms

Caspase-8, ced3, NEDD2-like protein, p15, p10

Gene Name

CASP8

UniProt

Q14790

Reactivity

Human

Immunogen

Clone (M382) was generated from a recombinant protein containing amino acid residues in the C-terminal region of human Caspase-8.

Target

Caspase-8 (C-terminal region)

Clonality

Monoclonal

Clone

M382

Conjugation

Unconjugated

Applications

ELISA, WB

Field of Research

Apoptosis, Cell Signaling

Format

Protein A Purified

Buffer

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Molecular Weight

Precautions

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Shipping Conditions

Blue Ice

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Notes

Protein A purified culture supernatant.

WB Dilution

1:500

Specificity

The antibody detects a 55 kDa* protein corresponding to the molecular weight of Caspase-8 on SDS-PAGE immunoblots of human Jurkat, K562, and A431 cells.