Alaternin
Alaternin (Catharticin) is an anthraquinone compound with antioxidant and hepatoprotective activities. Alaternin has an inhibitory activity against hydroxyl radicals generated in a cell-free chemical system (FeSO4/H2O2) with an IC50 value of 3.05 μM. Alaternin exhibits hepatoprotective activity against Tacrine -induced toxicity in human hepatic HepG2 cells with an EC50 value of 4.02 μM[1].
Product Specifications
CAS Number
39723-40-5
Product Name Alternative
Catharticin
UNSPSC
12352005
Target
CDK; NO Synthase; Reactive Oxygen Species (ROS) ; Tyrosinase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/alaternin.html
Smiles
O=C1C(O[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O[C@H]4[C@@H]([C@@H]([C@H]([C@@H](O4)C)O)O)O)O)O)O)O)=C(OC5=C1C(O)=CC(OC)=C5)C6=CC=C(C=C6)O
Molecular Formula
C34H42O19
Molecular Weight
754.69
References & Citations
[1]Jung H A, et al. Alaternin and emodin with hydroxyl radical inhibitory and/or scavenging activities and hepatoprotective activity on tacrine-induced cytotoxicity in HepG2 cells[J]. Archives of pharmacal research, 2004, 27: 947-953.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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