Oxybenzone

Oxybenzone (Benzophenone 3) is a commonly used UV filter in sun tans and skin protectants. Oxybenzone act as endocrine disrupting chemicals (EDCs) and can pass through the placental and blood-brain barriers. Benzophenone-3 impairs autophagy, alters epigenetic status, and disrupts retinoid X receptor signaling in apoptotic neuronal cells[1][2][3].

Product Specifications

CAS Number

[131-57-7]

Product Name Alternative

Benzophenone 3

UNSPSC

12352005

Hazard Statement

H400, H411

Target

Apoptosis; Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Oxybenzone.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(C1=CC=C(OC)C=C1O)C2=CC=CC=C2

Molecular Formula

C14H12O3

Molecular Weight

228.25

Precautions

H400, H411

References & Citations

[2]DiNardo JC, et al. Can oxybenzone cause Hirschsprung's disease?. Reprod Toxicol. 2019;86:98-100.|[3]Wnuk A, et al. Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells. Mol Neurobiol. 2018;55 (6) :5059-5074.|[4]Wnuk A, et al. Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons. J Steroid Biochem Mol Biol. 2018;182:106-118.|[1]Wnuk A, et al. Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons. J Steroid Biochem Mol Biol. 2018;182:106-118.