IPA-3
IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 2.5 μM, and shows no inhibition to group II PAKs (PAKs 4-6) .
Product Specifications
CAS Number
42521-82-4
UNSPSC
12352005
Hazard Statement
H318, H410
Target
PAK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IPA-3.html
Purity
99.39
Solubility
DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC=C2C=CC=CC2=C1SSC3=C4C=CC=CC4=CC=C3O
Molecular Formula
C20H14O2S2
Molecular Weight
350.45
Precautions
H318, H410
References & Citations
[1]Viaud J, et al. An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently. Mol Cancer Ther. 2009 Sep;8 (9) :2559-65.|[2]Flaiz C, et al. PAK kinase regulates Rac GTPase and is a potential target in human schwannomas. Exp Neurol. 2009 Jul;218 (1) :137-44.|[3]Deacon SW, et al. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol. 2008 Apr;15 (4) :322-31
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAK1
Available Sizes
Frequently Asked Questions
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