Dimaprit (dihydrochloride)
Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion[1][2].
Product Specifications
CAS Number
23256-33-9
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Histamine Receptor; NO Synthase
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/dimaprit-dihydrochloride.html
Purity
99.91
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
NC(SCCCN(C)C)=N.[H]Cl.[H]Cl
Molecular Formula
C6H17Cl2N3S
Molecular Weight
234.19
Precautions
H315, H319, H335
References & Citations
[1]Parsons ME, et, al. Dimaprit - (S-[3- (N, N-dimethylamino) prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7 (1) : 31-7.|[2]Paquay JB, et, al. Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br J Pharmacol. 1999 May; 127 (2) : 331-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H2 Receptor; nNOS
Available Sizes
Frequently Asked Questions
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