Dimaprit (dihydrochloride)

Dimaprit dihydrochloride is a selective histamine H2 receptor agonist, it also inhibits nNOS with an IC50 of 49 μM. Dimaprit dihydrochloride can stimulate gastric acid secretion[1][2].

Product Specifications

CAS Number

[23256-33-9]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Histamine Receptor; NO Synthase

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/dimaprit-dihydrochloride.html

Purity

99.91

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC(SCCCN(C)C)=N.[H]Cl.[H]Cl

Molecular Formula

C6H17Cl2N3S

Molecular Weight

234.19

Precautions

H315, H319, H335

References & Citations

[1]Parsons ME, et, al. Dimaprit - (S-[3- (N, N-dimethylamino) prophyl]isothiourea) - a highly specific histamine H2 -receptor agonist. Part 1. Pharmacology. Agents Actions. 1977 Mar; 7 (1) : 31-7.|[2]Paquay JB, et, al. Nitric oxide synthase inhibition by dimaprit and dimaprit analogues. Br J Pharmacol. 1999 May; 127 (2) : 331-4.