Camostat (mesylate)

Molecular Formula: C20H22N4O5 . CH3SO3H Molecular Weight: 494.5 Camostat is a trypsin-like protease inhibitor known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein, and thrombin. A special diet containing 1 mg/g camostat has been shown to inhibit the production of TNF-alpha and monocyte chemoattractant protein-1 by monocytes and to disrupt proliferation of pancreatic stellate cells in a rat model of pancreatic fibrosis.Protease regulation via camostat has also been reported to reversibly inhibit epithelial sodium channel function in human airway epithelial cell models (IC50 = 50 nM) and to enhance mucociliary clearance for up to five hours when administered by aerosol inhalation to sheep.