Asunaprevir
Molecular Formula: C35H46ClN5O9S Molecular Weight: 748.3 Asunaprevir is an inhibitor of the hepatitis C non-structural 3/4A serine protease, which is required for viral replication.It is a direct-acting inhibitor of hepatitis C virus (HCV) .It is commonly used in combination with daclatasvir and beclabuvir, which are also direct-acting HCV inhibitors.
Product Specifications
Product Name Alternative
BMS 650032
Purification
>=98%
Components
Asunaprevir is supplied as a crystalline solid.
Storage Conditions
Store at -20°C.
Applications Notes
A stock solution may be made by dissolving the asunaprevir in the solvent of choice. Asunaprevir is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of asunaprevir in these solvents is approximately 15, 25, and 30 mg/ml, respectively. Asunaprevir is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, asunaprevir should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Asunaprevir has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
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