Imidazoquinoline Resiquimod (R-848)
Formula: C17H22N4O2 MW: 314.4 Immune response modifier. Potent antitumor and antiviral compound. Stimulates antibody secretion and cytokine production. Used as adjuvant to increase the effectiveness of vaccines, potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human Activates immune cells via the TLR7/TLR8 MyD88-dependent signaling pathway and leads to the induction of NF-kB, NLRP3/NALP3 inflammasome activator, independent of TLRs and RIG-I.Upregulator of the opioid growth factor receptor. Used in the treatment of skin lesions such as herpes simplex virus.
Product Specifications
Product Name Alternative
Resiquimod; S 28463; R848
Applications
Functional Assay
Purification
Purity >= 98%
Components
Liquid (1 mg/ml)
Storage Conditions
Store the product at 4°C for short term and at -20°C for long-term storage. Product is stable for 2 years at -20°C.
Applications Notes
Solubility: Soluble in DMSO, dichloromethane or methanol. Slightly soluble in acetonitrile or ethyl acetate.
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