TNF-alpha, Soluble (human) (Recombinant)

A FLAG®-tag is fused at the N-terminus of human TNF-alpha (aa 85-223) .Specific Binds to human and mouse TNF-R1.Tumor necrosis factor (TNF, cachexin or cachectin and formerly known as tumor necrosis factor-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. The receptor TNF-R1 is activated by both the membrane-bound and soluble trimeric forms of TNF-alpha, whereas the receptor TNF-R2 only responds to the membrane-bound form of TNF-alpha (MultimericTNF-alpha (32-190048) . Since the MultimericTNF-alpha mimics the membrane-bound form (forms oligomers higher than trimer), it is the only TNF-alpha protein that can activate the TNF-R2. For TNF-R1 activation, either normal" TNF-alpha or Multimeric TNF-alpha can be used."