Mouse CCR2 Protein, hFc Tag

Description :Recombinant mouse CCR2 protein with C-terminal human Fc tag Background : Enables C-C chemokine binding activity and C-C chemokine receptor activity. Involved in several processes, including leukocyte migration; positive regulation of cell migration; and regulation of cytokine production. Acts upstream of or within several processes, including cellular defense response; monocyte chemotaxis; and neutrophil clearance. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Coronavirus infectious disease and age related macular degeneration. Human ortholog (s) of this gene implicated in several diseases, including Kawasaki disease; aggressive periodontitis; coronary artery disease (multiple) ; glucose metabolism disease (multiple) ; and uveitis (multiple) . Orthologous to human CCR2 (C-C motif chemokine receptor 2) . Molecular Characterization: mass of 32.3 kDa after removal of the signal peptide. The apparent molecular mass of mCCR2-hFc is approximately 35-55 kDa due to glycosylation. Tag :C-Human Fc tag

Product Specifications

Product Name Alternative

Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2

UniProt

P51683

Host

HEK293

Target Antigen

CCR2

Purification

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.