Mouse PD-1 Protein, hFc Tag

Description :Recombinant mouse PD-1 protein with C-terminal human Fc tagBackground : Involved in negative regulation of immune response. Acts upstream of or within negative regulation of apoptotic process; negative regulation of tolerance induction; and positive regulation of apoptotic process. Located in external side of plasma membrane. Is expressed in retina. Used to study dilated cardiomyopathy and systemic lupus erythematosus. Human ortholog (s) of this gene implicated in autoimmune disease (multiple) ; hepatitis B; hepatitis C; hepatocellular carcinoma; and lupus nephritis. Orthologous to human PDCD1 (programmed cell death 1) . Molecular Characterization: mass of 42.3 kDa after removal of the signal peptide. The apparent molecular mass of mPD-1-hFc is approximately 35-70 kDa due to glycosylation.Tag :C-Human Fc Tag

Product Specifications

Product Name Alternative

Pdcd1; Pdc1; Ly101

UniProt

Q02242

Host

HEK293

Target Antigen

PD-1

Purification

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.