Cynomolgus CXCR3 Protein, hFc Tag

Description :Recombinant Cynomolgus CXCR3 protein with C-terminal human Fc tagBackground : This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant) . Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 . Molecular Characterization: mass of 32.0 kDa after removal of the signal peptide. The apparent molecular mass of cCXCR3-hFc is approximately 35-55 kDa due to glycosylation.Tag :C-Human Fc tag