Cynomolgus Nectin-4 Protein, His Tag

Description :Recombinant Cynomolgus Nectin-4 protein with C-terminal 10×His tagBackground : This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.Molecular Characterization: mass of 35.4 kDa after removal of the signal peptide. The apparent molecular mass of cNectin-4-His is approximately 35-55 kDa due to glycosylation.Tag :C-10×His tag