Cynomolgus CD3E Protein, hFc Tag

Description :Recombinant Cynomolgus CD3E protein with C-terminal human Fc tagBackground : The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. Molecular Characterization: mass of 37.0 kDa after removal of the signal peptide. The apparent molecular mass of cCD3E-hFc is approximately 35-55 kDa due to glycosylation.Tag :C-Human Fc tag

Product Specifications

Product Name Alternative

T3E; TCRE; IMD18; CD3epsilon

UniProt

Q95LI5

Host

HEK293

Target Antigen

CD3E

Purification

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.