Human HGF (1-728) Protein, hFc Tag

Description :Recombinant human HGF (1-728) Protein with C-terminal human Fc tagBackground : This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. Molecular Characterization: mass of 109.3 kDa after removal of the signal peptide. The apparent molecular mass of HGF (1-728) -hFc is approximately 70-130 kDa due to glycosylation.Tag :C-Human Fc tag