Human IFNA2 Protein, hFc Tag

Description :Recombinant human IFNA2 Protein with C-terminal human Fc tagBackground : This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. The encoded protein is effective in reducing the symptoms and duration of the common cold and in treating many types of cancer, including some hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is thought to be a hallmark of severe COVID-19 and may provide a rationale for a combined therapeutic approach. Molecular Characterization: mass of 45.4 kDa after removal of the signal peptide. The apparent molecular mass of IFNA2-hFc is approximately 55-70 kDa due to glycosylation.Tag :C-Human Fc tag