Human LEP Protein, hFc Tag

Description :Recombinant human LEP Protein with C-terminal human Fc tagBackground : This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. Molecular Characterization: mass of 42.2 kDa after removal of the signal peptide. The apparent molecular mass of LEP-hFc is approximately 35-55 kDa due to glycosylation.Tag :C-Human Fc tag

Product Specifications

Product Name Alternative

OB; OBS; LEPD

UniProt

P41159

Host

HEK293

Target Antigen

LEP

Purification

The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.

Components

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8% trehalose is added as protectants before lyophilization.

Storage Conditions

Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing) . Lyophilized proteins are shipped at ambient temperature.