Human MET Protein, hFc Tag

Description :Recombinant human MET Protein with C-terminal human Fc tagBackground : This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. Molecular Characterization: mass of 127.8 kDa after removal of the signal peptide. The apparent molecular mass of MET-hFc is approximately 100-250 kDa due to glycosylation.Tag :C-Human Fc Tag